Fig. 4

The miR-451 interacted with MIF in human BMECs. A The common target genes of miR-451 were listed in both miRDB and TargetScan databases. B The miR-451 covalently binding 3’UTR of MIF. C, D Detection of the luciferase activity in human BMECs after co-transfection of miR-451 mimic (or inhibitor) with WT-MIF/MUT-MIF. E Expression level of MIF in human BMECs after OGD treatment. F Expression level of MIF in OGD-treated human BMECs after si-CRNDE transfection and subsequent miR-451 inhibition. ***means P < 0.001