Fig. 3

LncRNA CRNDE interacted with miR-451 in human BMECs. A The 3’UTR of lncRNA CRNDE covalently binding miR-451. B, C Detection of the luciferase activity in human BMECs co-transfected with miR-451 mimic (or inhibitor) and WT-CRNDE/MUT-CRNDE. For cell transfection, si-NC was used as the negative control. D Expression level of miR-451 in human BMECs after OGD treatment. E Expression level of miR-451 in human BMECs after OGD treatment and si-CRNDE transfection. F Relative expression of miR-451 in ischemic stroke patients. G Pearson correlation analysis between lncRNA CRNDE and miR-451 in ischemic stroke patients. *means P < 0.05, **means P < 0.01, ***means P < 0.001